Hey Tom,
It's a little difficult to know what you mean by this. First do you mean, asymptotic safety in the sense of Weinberg applied to gravity (eg nonperturbative renormalizability), or the modern program that takes truncations of the functional exact renormalization group equations (they are not necessarily the same thing, the second could be false but the first could be true).
Further, the no boundary proposal is usually formulated in the old approaches to quantum cosmology (really it's more about initial conditions in the minisuperspace approach to canonical quantum gravity) although it is often (not necessarily equivalently) formulated as a Euclidean path integral problem (where again the choice of the boundary conditions defines the proposal). Usually the assumption of semiclassical gravity is implicit, and it is rare that matter is included (it makes an already intractable calculation even more difficult), so its a little difficult to see what you mean.