ATP in Fatty acid oxidation and citric acid cycle

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SUMMARY

ATP is utilized during the activation of fatty acids in the beta-oxidation process, specifically when fatty acids react with ATP to form acyladenylate, consuming two ATP equivalents. The first ATP is hydrolyzed to form acyladenylate, while the second ATP is indirectly used during the hydrolysis of pyrophosphate (PPi) into two inorganic phosphates (2Pi). In the citric acid cycle, ATP is produced during the conversion of succinyl CoA to succinate, where GTP is generated and can be converted to ATP. The discussion also touches on the degradation of odd-numbered fatty acids, leading to the formation of propionyl CoA.

PREREQUISITES
  • Understanding of beta-oxidation processes
  • Knowledge of the citric acid cycle
  • Familiarity with ATP hydrolysis and its role in biochemical reactions
  • Basic concepts of fatty acid metabolism
NEXT STEPS
  • Research the mechanism of fatty acid activation and the role of ATP in this process
  • Study the complete beta-oxidation pathway for both even and odd-numbered fatty acids
  • Learn about the conversion of GTP to ATP in the citric acid cycle
  • Explore the metabolic fate of propionyl CoA and its conversion to succinyl CoA
USEFUL FOR

Biochemistry students, metabolic researchers, and professionals in the field of nutrition and exercise physiology will benefit from this discussion, particularly those focusing on fatty acid metabolism and energy production pathways.

jenzao
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At what point in either beta-oxidation or citric acid cycle is ATP used?
I see where ATP is produced in citric acid cycle (originally as GTP) as when succinyl CoA is converted to Succinate, but I can't find any part where ATP is required. Apparently according to my lecture notes, it is required during beta oxidation somewhere but I can't see exactly where? Please help, thanks!

UPDATE: i found out that the 2 ATP are used during fatty acid activtion, but I only see where one is required. (??)

(when fatty acid is added to 1 ATP to form acyladenylate) Where is other one required?? thanks
 
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jenzao said:
At what point in either beta-oxidation or citric acid cycle is ATP used?
I see where ATP is produced in citric acid cycle (originally as GTP) as when succinyl CoA is converted to Succinate, but I can't find any part where ATP is required. Apparently according to my lecture notes, it is required during beta oxidation somewhere but I can't see exactly where? Please help, thanks!

UPDATE: i found out that the 2 ATP are used during fatty acid activtion, but I only see where one is required. (??)

(when fatty acid is added to 1 ATP to form acyladenylate) Where is other one required?? thanks
Could the question be referring to the hydrolysis of the resulting pyrophosphate?

Fatty acid + ATP <-----> Acyl adenylate + PPi
PPi + pyrophosphatase -------> 2Pi

What about odd number fatty acid degradation? How is the final product (propionyl CoA) dealt with?
 

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