Is Home Testing for Cancers with a Blood Assay a Good Idea?

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Discussion Overview

The discussion revolves around the feasibility and implications of using a blood assay for cancer detection as a home testing option. Participants explore the practicality of such tests, their costs, and the potential consequences of widespread home testing versus traditional lab testing.

Discussion Character

  • Exploratory
  • Debate/contested
  • Technical explanation

Main Points Raised

  • Some participants note that the blood assay can detect a range of cancers with a high detection rate and low false positives, but its implementation as a home test is questioned.
  • There is a suggestion that the test may be more suitable for in-person administration during annual physicals rather than daily home testing.
  • Concerns are raised about the cost of the test, which is currently around $500, and the necessity for it to be conducted in a lab setting.
  • Some participants express a desire for at-home testing due to personal anxiety about health, but acknowledge the practical challenges involved in self-administering blood tests.
  • One participant argues that home testing could lead to unnecessary anxiety and medical interventions, citing issues seen with mass screening and the PSA test for prostate issues.
  • It is mentioned that effective home testing would require a test sensitive enough to work with small blood samples, and that professional interpretation of results is crucial.

Areas of Agreement / Disagreement

Participants generally agree that while the blood assay shows promise, there is significant disagreement regarding the practicality and safety of implementing it as a home test. Concerns about the implications of frequent testing and the need for professional oversight remain unresolved.

Contextual Notes

Limitations include the current cost of the test, the requirement for lab processing, and the potential psychological impact of frequent testing. The discussion does not resolve the feasibility of home testing versus lab testing.

BillTre
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Science magazine news reports on a blood assay for a number of cancers, done all at once.
It detected between 33% and 98% of cases with <1% false positives.
it uses a combination of detecting DNA and proteins.
 
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Could this say be something you could test daily at home for or something you'd do in person with a yearly physical?
 
Currently, it is not a cheap test (I think I read ~$500) and it probably has to be done in a lab.
From my reading, it would probably be a test for DNA markers and another test for some protein markers.
So I'm thinking like a blood lab test you get a physical rather than something you could do at home.
 
BillTre said:
So I'm thinking like a blood lab test you get a physical rather than something you could do at home.
I can't wait for at home tests. I'm so paranoid!
 
Given that it's a blood test (the paper says they used about 7.5 mL of plasma), it's likely something that would have to be done at a doctor's office as most people would not have the experience or equipment to draw their own blood. At at home version would only be feasible if it were sensitive enough to work on a few drops of blood (<<1mL). Still, as with many of these types of diagnostics, it is very helpful to have a doctor or someone knowledgeable be able to help the patient interpret the test results.
 
While I'm sure these tests will become better and cheaper the idea of home testing every day would probably be a very bad idea. If you look at some of the problems associated with mass screening, the same problems would be present. Its quite likely that there will always be abnormal cells in our body which will never progress to causing disease, so any positive test would need repeated testing and further investigation. This would lead to increased cost and possibly expose people to invasive investigations or dangerous treatments, this was a problem with the PSA test for prostate problems. It may be that even simple things like yearly physicals should only really be done at ages where there are established risks, it might invite unnecessary interventions and add to risk.
 
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