I guess the reasons for which the RHS formulation of the Copenhagian view of QM is not embraced by the community not only reside with the difficulties of the mathematical approach, but also with the conflict between RHS and the probabilistic view a\ la Born, which necessarily asks for Hilbert space and not for distributions on it.
If i better think about it, we've got conflicts in the Hilbert space axiomatization as well*. It turns out that, if one accepts/postulates that physical quantum states are described by unit rays in a complex separable Hilbert space, then the free massive Galilean particle doesn't exist, as it has no physical states, as follows from solving the Schroedinger equation (which is also postulated, of course). So the probabilistic interpretation a\ la Born of the free Galiean particle is not defined, as the probability to find this particle along the whole real axis is infinite.
* A way to circumvent that is to acknowledge that the (probably) commonly accepted axioms apply only to a very restricted class of physical systems, which, of course, is not desired for a theory.