To calculate the distance between two cities using their latitudes and longitudes, first convert these polar coordinates into three-dimensional Cartesian coordinates (x, y, z) based on the Earth's radius. The latitude and longitude provide the necessary information to define each city's position vector. After obtaining the Cartesian coordinates, perform vector subtraction to find the displacement vector. Finally, apply the distance formula in Cartesian coordinates to determine the magnitude of the displacement. This method effectively utilizes the spherical nature of the Earth for accurate distance calculations.