Can I trust this article from Duke on mice and OCD?

[jonjacson]

TL;DR Summary

I found a Duke University article explaining an study they did with mice, related with OCD and I want to know if this is solid science.

If this is true I think it is very interesting and encouraging so, Any expert can help?

https://www.inc.com/john-brandon/brain-scientists-have-made-a-big-discovery-about-ocd.html

https://today.duke.edu/2016/07/ocdreceptor

"Brain scientists at Duke University tested lab mice who were bred with a low level of a brain receptor and found that they would excessively groom themselves. The gene, known as Sapap3, is what creates the connection between brain cells.

It's a remarkable discovery because, during the testing process, the researchers were able to identify the exact chemical, called mGluR5, that encouraged the OCD-like behavior."

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In case the article is a piece of crap I ask, What does science know about OCD at June 3rd 2021? Anybody here with a solid knowledge of this topic?

Thank you folks!

 

[berkeman]

A link to the journal article (please always try to post a link to the source article in a peer-reviewed journal):

https://www.biologicalpsychiatryjournal.com/article/S0006-3223(16)32380-0/fulltext

This is all from 2016 -- can you find more recent follow-on research and journal articles?

 

[atyy]

Freely available version of the article referenced by the OP: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536332/

You can check on how others have cited the work using Google Scholar: https://scholar.google.com/scholar?cites=6482082947565345824&as_sdt=2005&sciodt=0,5&hl=en

The striatum is hypothesized to be involved in OCD, partly because it is generally thought to be also involved in the formation of habitual behavior. However, I think it is still mostly in the realm of conjecture. As a starting point for looking up current research, you could use a now quite old, but very informed, review of this conjecture: https://pubmed.ncbi.nlm.nih.gov/11144344/.

 

[jonjacson]

A link to the journal article (please always try to post a link to the source article in a peer-reviewed journal):

https://www.biologicalpsychiatryjournal.com/article/S0006-3223(16)32380-0/fulltext

This is all from 2016 -- can you find more recent follow-on research and journal articles?

Ok I will do.

I just found yesterday, I will continue searching and will share in this thread.

Freely available version of the article referenced by the OP: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536332/

You can check on how others have cited the work using Google Scholar: https://scholar.google.com/scholar?cites=6482082947565345824&as_sdt=2005&sciodt=0,5&hl=en

The striatum is hypothesized to be involved in OCD, partly because it is generally thought to be also involved in the formation of habitual behavior. However, I think it is still mostly in the realm of conjecture. As a starting point for looking up current research, you could use a now quite old, but very informed, review of this conjecture: https://pubmed.ncbi.nlm.nih.gov/11144344/.

Thanks I didn't know how to use Google Scholar.

Ok I will take a look.