Can the AstraZeneca vaccine be called also as a DNA vaccine?

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The discussion centers on the classification of the Oxford–AstraZeneca vaccine and its mechanism of action compared to DNA vaccines. The AstraZeneca vaccine uses a viral vector to deliver the DNA code for SARS-CoV-2 spike proteins, while traditional DNA vaccines utilize plasmids for delivery. Despite both ultimately leading to the production of spike proteins, the delivery methods differ significantly. Therefore, it is suggested to adhere to established terminology by referring to the AstraZeneca vaccine as an adenovirus-vectored vaccine rather than a DNA vaccine. This distinction helps clarify the differences in how these vaccines operate at a cellular level. The consensus emphasizes the importance of using precise terminology to avoid confusion.
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Can the Oxford–AstraZeneca COVID-19 (viral vector) vaccine also be called a DNA vaccine, since it contains genetic material (DNA) for producing spike proteins of the SARS-CoV2 virus inside the host cell?
In my understanding, in the human host, the Oxford–AstraZeneca vaccine delivers the DNA genetic code for the production of spike proteins of the SARS-CoV2 virus, inside a vector virus. DNA vaccines deliver them through plasmids.

Apart from this delivery mode, is there any difference between the DNA vaccines and Oxford–AstraZeneca (or Sputnik V) vaccine in the mechanism of the production of spike proteins inside the host cell?

If not, can we call the AstraZeneca vector vaccine a DNA vaccine also?

Pardon my silly question, but it is nagging me.
 
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It's just a matter of terminology, and as long as one communicates clearly, that is fine. For most purposes, I think it would be better to follow current convention and not call the AstraZeneca (AZ) vaccine a DNA vaccine. The AZ vaccine is usually called an adenovirus-vectored vaccine. I think it is clearer to use that terminology because the way that the DNA gets into cells is presumably different between an adenovirus-vectored vaccine like AZ and a DNA vaccine like ZyCoV-D.
 
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By delivery, it's a viral vector vaccine. By action, it is a DNA vaccine. Even I could discern the confusion. :smile:

Let's follow the international terminology - it is a viral vector vaccine.

Thanks.
 

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