Gort said:
I agree with the first sentence. From the second sentence, I take it that you think there will be a "ToE" and we'll know when we find it?
The reason I think the discussion has nothing to do with quantum theory is that the discussion is about how we can know any theory is a TOE. The answer is we cannot. We could have the TOE in principle, but we could not know that it can never be falsified, since we cannot test all its predictions. That is standard scientific faith which you can find in a biology textbook.
The more interesting thing is - can we know that a theory is not a TOE, even though it passes all experimental tests to date? Quantum mechanics gives us two examples.
1) The measurement problem
2) The renormalizability problem in QFT
Some would say that classical GR is an example of a theory that passes all experimental tests, and cannot be a TOE because of its singularties (this issue is debatable, but I include it here since the argument is reasonable).
However, it is really the measurement problem that is present in quantum theory in a way that is not present in classical theory. The renormalizability problem doesn't seem to me especially quantum, just a version of the singularity problem in classical GR. Here are two good expositions of the measurement problem:
http://www.tau.ac.il/~quantum/Vaidman/IQM/BellAM.pdf
Bell, Against 'measurement'
http://cds.cern.ch/record/260158/files/P00021853.pdf?version=1
Tsirelson, This non-axiomatizable quantum theory
Of course, if one takes a Bohmian or GRW or Transactional Interpretation viewpoint, then even the measurement problem can be classed with the renormalizability problem of QFT and the singularity problem of GR - these occur because the theories are incomplete - we know the theories are only effective theories, although they have not been falsified. However, QM has options that cannot be ruled out yet. For example, there is the Many-Worlds approach, in which we have objective reality, but it is radically different from our commonsense reality.