Can you achieve telomere maintenance without using gene therapy

In summary, there are several ways to achieve telomere maintenance without using gene therapy. These include injecting pure telomerase, using adenovirus or nanoparticles, and using a biolistic particle delivery system. However, there are limitations to each method, such as the inability of enzymes to enter the cell and the size of telomerase being too large for some delivery methods. Gene therapy using a gene gun is not possible as the large size of telomerase prohibits it from being delivered effectively.
  • #1
319
0
Can you achieve telomere maintenance without using gene therapy?
if so, what are the ways?
thanks
 
Biology news on Phys.org
  • #2
is it possible injecting pure telomerase would work or would it not be able to get inside the cells?
I thought adeno associated virus would be used if it were ever done? But would you not be able to use that on a large quantity of cells?
 
  • #3
enzymes cannot get into the cell especially not the nucleus where your genes are. The reason adenovirus is unfavorable is precisely because you mentioned telomerase as in the gene will only be used when the cell divides. Adenoviruses' genes cannot be passed onto the daughter cells because their dna is never integrated into the host unlike retroviruses that do integrate their genes into the host.
 
  • #5
also can a gene gun be used to do gene therapy on a person? why or why not?
 
  • #6
can a gene gun be used to deliver telomerase? its a large protein
 
  • #7
Biolistic particle delivery system? You coat a heavy metal (usually gold) with DNA, which is then shot through tissues. While the heavy metal passes through the cells the DNA gets stripped and stays behind in the cells. No, for obvious reasons.
 

1. Can telomere maintenance be achieved without using gene therapy?

Yes, there are alternative methods that have been discovered to maintain telomere length without using gene therapy. These methods involve lifestyle changes, such as a healthy diet and exercise, as well as supplements and medications.

2. How does gene therapy affect telomere maintenance?

Gene therapy involves manipulating the genes in the body to treat or prevent diseases. In terms of telomere maintenance, gene therapy can introduce new genes that can help maintain telomere length. However, there are potential risks and ethical concerns associated with gene therapy.

3. What are the benefits of achieving telomere maintenance without gene therapy?

Achieving telomere maintenance without gene therapy can have numerous benefits, including a reduced risk of potential side effects and ethical concerns associated with gene therapy. Additionally, lifestyle changes and alternative methods for telomere maintenance can have positive impacts on overall health and well-being.

4. Are there any natural ways to maintain telomere length?

Yes, there are natural ways to maintain telomere length, such as adopting a healthy lifestyle, reducing stress, and getting enough sleep. Additionally, certain supplements and medications have been found to have positive effects on telomere maintenance.

5. How important is telomere maintenance for overall health?

Telomere maintenance is crucial for overall health as telomeres play a significant role in cellular aging and the development of age-related diseases. Maintaining telomere length can help prevent premature aging and promote overall health and longevity.

Suggested for: Can you achieve telomere maintenance without using gene therapy

Replies
2
Views
962
Replies
1
Views
2K
Replies
6
Views
1K
Replies
7
Views
1K
Replies
1
Views
699
Replies
8
Views
1K
Back
Top