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Determining the pharmacophore of a group of isosteres

  1. Jul 27, 2012 #1
    Heres the question:
    http://img442.imageshack.us/img442/484/sarr.png [Broken]
    Firstly does anyone know what Ki is? Ionisation constant? I'm guessing its proportional to the drugs potency. I could take a good guess by observing the differences between each isostere but I'm guessing theres some kind of method I should be able to use here.
    Last edited by a moderator: May 6, 2017
  2. jcsd
  3. Jul 27, 2012 #2


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    In biochemistry, KI is the binding constant for an inhibitor. Put more precisely, in the binding interaction between an inhibitor I and enzyme E, which form enzyme-inhibitor complex EI:

    E + I <--> EI

    KI is the equilibrium dissociation constant for the binding reaction:

    [tex]K_I = \frac{[E]}{[EI]}[/tex]

    Therefore, more potent inhibitor have lower KI values.
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