Distribution of isotopes throughout the body

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Discussion Overview

The discussion revolves around the distribution of carbon isotopes in the human body, their potential mutagenic effects, and their role in DNA diversity. Participants explore the presence of naturally occurring radioactive isotopes, their concentrations, and the implications of these isotopes on biological processes.

Discussion Character

  • Exploratory
  • Debate/contested
  • Technical explanation

Main Points Raised

  • Some participants inquire whether different carbon isotopes are distributed in varying concentrations throughout the human body.
  • It is noted that natural radioactive isotopes, such as tritium, carbon-14, and potassium-40, are present in the body due to dietary and environmental sources.
  • One participant questions how the net radiation from the human body compares to external radiation exposure.
  • There is a claim that mutations from radiation typically require large quantities, suggesting that normal background radiation is not significantly harmful.
  • Some participants argue that different isotopes might perform different functions in human tissue or DNA, while others clarify that isotopes are chemically identical and behave similarly in reactions.
  • Concerns are raised about the misapplication of the term "isotope" in a referenced book regarding carbon in grasses.
  • Discussions include the chemical behavior of deuterium compared to hydrogen, with some suggesting that differences in mass may affect reaction rates.
  • One participant discusses isotope effects, noting that lighter isotopes may exhibit different reaction rates in chemical processes.

Areas of Agreement / Disagreement

Participants express multiple competing views regarding the role and behavior of isotopes in biological systems, with no consensus reached on the implications of these isotopes for DNA diversity or their chemical behavior.

Contextual Notes

There are unresolved questions about the specific concentrations of isotopes in different body tissues and the conditions under which isotopes might affect biological processes. Some claims rely on assumptions about radiation exposure and its effects.

Loren Booda
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Are different carbon, e. g., isotopes distributed throughout the human body in relatively different concentrations? Are radioactive atoms mutagenic and electronically dissimiliar, thus affecting the chemistry of neighboring structures? Could these isotopes be a considerable source of DNA diversity?
 
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Natural Radioactivity in the Body

There is natural background radioactive isotopes in our body.
Natural Radioactivity in the Body ( http://www.doh.wa.gov/ehp/rp/air/factsheets-htm/FactSht10.htm )
Small traces of many naturally occurring radioactive materials are present in the human body. These come mainly from naturally occurring radioactive nuclides present in the food we eat and in the air we breathe. These isotopes include tritium (3H), carbon-14 (14C), and potassium-40 (40K). About 11% (40 mrem) of our radiation dose comes from naturally occurring radioactive materials in the body. Most of the dose comes from a radioactive isotope of potassium. Radioactive potassium-40, as well as other radioactive materials (such as carbon-14) which occur naturally in air, water, and soil, are incorporated into the food we eat and then into our body tissues.
 
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I wonder if the net radiation from the human body compares to that impinging upon it from the exterior environment?
 
Loren Booda said:
Are different carbon, e. g., isotopes distributed throughout the human body in relatively different concentrations?

What do you mean by this? If different isotopes are in different concentrations in different places in the body? Can you please clarify?

Loren Booda said:
Are radioactive atoms mutagenic and electronically dissimiliar, thus affecting the chemistry of neighboring structures?

Yes, mutations can occur by radiation, but only in relatively large quantities. The normal background radiation is much much more stronger than any radiation that come from naturally occurring elements, that you would normally take in. Even radiation from future fusion plants would be about 1% of the current background radiation.

However, if you eat a kilogram of weapongrade uranium U-235 you would indeed be subjected to..well...death.
Loren Booda said:
Could these isotopes be a considerable source of DNA diversity?

As a result, no.
 
Depending upon where you live, about 5/6 of your roughly 360 mrem background exposure comes from natural sources, and about 200 mrem of this comes from radon.
 
Mattara
What do you mean by this? If different isotopes are in different concentrations in different places in the body? Can you please clarify?
For instance, in the evolution of grasses first one isotope of carbon (designated C3) was common, then another (C4). I thought that different isotopes in general might perform different functions in human tissue or DNA as well.
 
Loren Booda said:
MattaraFor instance, in the evolution of grasses first one isotope of carbon (designated C3) was common, then another (C4). I thought that different isotopes in general might perform different functions in human tissue or DNA as well.


C3 and C4 are not isotope. These refers to the amount of carbon on the sugar synthesized by the plant.

http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/C4plants.html
 
Loren Booda said:
MattaraFor instance, in the evolution of grasses first one isotope of carbon (designated C3) was common, then another (C4). I thought that different isotopes in general might perform different functions in human tissue or DNA as well.
Plus, different isotopes are chemically identical, that is, a radioactive C14 atom is no different for chemical reactions than a non-radioactive carbon atom. Chemical behavior is determined primarily by the electrons in the outer shell, which is why elements are divided into periods.
 
Loren Booda said:
MattaraFor instance, in the evolution of grasses first one isotope of carbon (designated C3) was common, then another (C4). I thought that different isotopes in general might perform different functions in human tissue or DNA as well.

Besides, Carbon-14 decay is only for beta radiation (and not gamma which would have any effect at all).
 
  • #10
If you all have the opportunity, see the bottom half of page 230 in the popular (and scientific) book "Beasts of Eden," about mammal evolution. Its author, David Rains Wallace, seems to have made a major gaffe with the term "isotope" in reference to carbon in grasses.

Aside: I believe that deuterium may have significant chemical differences with common hydrogen.
 
  • #11
Loren Booda said:
If you all have the opportunity, see the bottom half of page 230 in the popular (and scientific) book "Beasts of Eden," about mammal evolution. Its author, David Rains Wallace, seems to have made a major gaffe with the term "isotope" in reference to carbon in grasses.

Aside: I believe that deuterium may have significant chemical differences with common hydrogen.
The chemical properties should be identical. The thing that contributes to their difference is that Deuterium has a larger mass so, for example, reactions involving Deuterium might proceed at a slower rate than those involving Hydrogen.
 
  • #12
http://www.biologie.uni-hamburg.de/b-online/e24/24b.htm

Isotope effects: compounds containing lighter isotopes exhibit slightly higher rate constants in chemical reactions; that is, 12C, 13C, and 14C abundances (measured in ppm enrichments or depletions of 13C, and 14C) differ in bio-mass from those of C from other sources.
 
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  • #13
Thanks all for your addenda.

I figure that C3 and C4 are actually isomers of molecular carbon, whence a misprint by "Beasts of Eden."
 
  • #14
They're not isomers either. C3 plants initially incorporate carbon into a 3-carbon molecule, while C4 plants incorporate it into a 4-carbon molecule. There are also many other anatomical and physiological differences between the two types of plants.
 
  • #15
Looks like you have the definitive answer, nipwoni.
 

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