DNA Fingerprinting: Genome variability

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SUMMARY

The discussion centers on DNA fingerprinting and genome variability, specifically focusing on single-nucleotide polymorphisms (SNPs) and short tandem repeat polymorphisms (STRPs). An SNP represents a variation at a single nucleotide in the DNA sequence, contributing to genetic diversity among individuals. The nucleotide diversity between humans is approximately 0.1%, equating to around 3 million nucleotide differences between any two individuals, given the human genome's size of roughly 3 billion base pairs.

PREREQUISITES
  • Understanding of single-nucleotide polymorphisms (SNPs)
  • Knowledge of short tandem repeat polymorphisms (STRPs)
  • Familiarity with human genome structure and sequencing
  • Basic genetics concepts, including nucleotide sequences
NEXT STEPS
  • Research the role of SNPs in genetic variation and disease susceptibility
  • Explore methods for analyzing STRPs in DNA fingerprinting
  • Learn about genome sequencing technologies and their applications
  • Investigate the implications of nucleotide diversity in population genetics
USEFUL FOR

Geneticists, forensic scientists, and researchers interested in human genetics and DNA analysis will benefit from this discussion.

chapsticks
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How much variability exists between the genomes of separate individuals? What is an SNP?
 
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Homework question?
 
DNA fingerprinting is generally done with STRP short tandem repeat polymorphisms.
I imagine SNPs would be used to determine differences in certain alleles.

From wiki: "The nucleotide diversity between humans is about 0.1%"

Our genome is ~3 billion basepairs, 0.1% of 3 billion is 3 000 000. SO between any 2 people there is said to be ~3 million nucleotide differences!
 
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