DNA testing, what kind of sample is the minimum?

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SUMMARY

The discussion centers on the feasibility of conducting DNA tests using fallen hair or skin cells. It confirms that even dead cells can retain unique DNA sequences, which are utilized in forensic science, particularly in low copy number DNA analysis. The practical challenges arise from the high sensitivity of detection methods, which can lead to complications in forensic investigations due to the presence of multiple DNA sources in a sample. Understanding these nuances is crucial for interpreting DNA evidence accurately.

PREREQUISITES
  • Basic understanding of DNA structure and function
  • Familiarity with forensic science principles
  • Knowledge of low copy number DNA analysis techniques
  • Awareness of contamination issues in DNA sampling
NEXT STEPS
  • Research the techniques used in low copy number DNA analysis
  • Explore the implications of DNA evidence in forensic investigations
  • Learn about contamination prevention methods in DNA sampling
  • Investigate the role of DNA in forensic dispute resolution
USEFUL FOR

This discussion is beneficial for forensic scientists, criminal investigators, and legal professionals involved in cases where DNA evidence is critical for establishing identity or resolving disputes.

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Is it possible to do DNA test from fallen hair, or skin cells? Or no, since the cells die and lose their core before they fall from the body?
Do dead cells still have somekind of unique "fingerprint"?
 
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Yes, and this is widely used in forensics just for traces of DNA also on quite old samples.The theoretical limit is just one molecule containing a given nucleotide sequence. For the practical limit somebody more up-to-date than me will no doubt come and tell you.

Often the practical problem will come not from the limitation of sensitivity, but from the very great sensitivity itself! Almost too much can be detected. A given DNA sequence will often be just one amidst dozens or hundreds of others in a sample. In the case of criminal forensics you can pick up an extremely tiny amount of DNA and establish that it almost certainly came from a certain person. But how did that tiny amount get to a crime scene? Might be all sorts of indirect and innocent ways. So you get into forensic dispute. For some more information you could google ‘Low copy number DNA’.

Big subject, interesting, somewhat complicated, implications have been and probably still are controversial. (Also because whenever you mention DNA or genetics many people just go bonkers.)
 
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As child, before I got my first X-ray, I used to fantasize that I might have a mirror image anatomy - my heart on the right, my appendix on the right. Why not? (Caveat: I'm not talking about sci-fi molecular-level mirroring. We're not talking starvation because I couldn't process certain proteins, etc.) I'm simpy tlakng about, when a normal zygote divides, it technically has two options which way to form. Oen would expcet a 50:50 split. But we all have our heart on the left and our...

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