Particle annihilation primarily occurs between a particle and its corresponding antiparticle, typically involving charged particles of equal mass but opposite charge. Photons, being massless and chargeless, do not annihilate with each other; instead, they are produced during annihilation events involving other particles. Annihilation processes are governed by conservation laws and can involve complex interactions, such as quarks and antiquarks annihilating into gluons or photons under specific conditions. The discussion also touches on the stability of hypothetical particles like the HybriDeuteron, suggesting that certain combinations of particles and antiparticles may have longer lifetimes due to their subnuclear properties. Overall, annihilation is a nuanced process influenced by the fundamental characteristics of the particles involved.