the equation e = mc^2 is a fundamental relation between mass and energy. A particle of mass m has an "intrinsic rest energy" Eo given by Eo = mc^2
im not 100% on the way that they derived k = 1/2 mv^2 but i do know that its only used when relating mass velocity and kinetic energy.
the Eo is the energy a mass has with no relation to velocity or position. the c is a velocity but its a relation to the speed of light your making, in 1/2 mv^2 the velocity your relating there is that of the particle of mass m.
basically the energies in the 2 equations are not the same, and in one your relating the speed of the mass, and in the other your relating a mass to a constant [the speed of light]
hope that helps.