The universe is a closed system, therefore it can't exchange heat or mass with any other system (of which there are none, since we're talking about the universe here). Since the single particle can't have any interaction with any other particle and its excluded volume in such a large system is effectively zero, the system you are describing is an ideal gas. So, let's think in terms of an ideal gas in a sealed adiabatic container fitted with a piston or some other means of changing the volume. Assuming the temperature, T>0, and reversibility of the volume change, then for such a change dS = δq /T = 0. So the entropy does not depend on the volume and an increase in volume does not change the entropy. Your universe being an ideal gas, the energy also does not depend on the volume.
There's one worm in the ointment, as far as I can see. All the above assumes that there is no non-uniform field in the container for which a gradient will constitute a force, therefore pressure, of its own. To my untutored mind, this is what our relativists are referring to: If there's only one particle there's no gravitational field that the particle can sense. As soon as you include more than one particle - with nonzero mass - then the particles will experience their mutual gravitational attraction. The pressure of the system, compared to a perfect vacuum (which doesn't exist, I know, but neither does the system we're talking about, so..), will be negative. So it would take work to separate the particles, i.e. to increase the volume of the system. The energy of the system will depend on the volume. So our assumption of ideality goes out the window. For laboratory-scale systems, gravitation is ignored, making ideal gases approachable. On the other hand, you didn't specify what the mass of the particle is, so it could be humongous and though it is only one particle, space curvature might make a difference. If the universe expands, will the curvature have to change? If so, will that change the energy or entropy? As to that, I have no idea; but whatever the answers, thermodynamics will still apply.