Epigenetic changes , how many generations does it last?

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In summary: This review summarizes the current understanding of epigenetic inheritance in mammals, with a focus on humans. Our findings suggest that epigenetic inheritance can occur in mammals, and that it is likely due to environmental factors. However, the extent to which it happens and the molecular mechanisms by which it occurs are still not well understood.
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windy miller
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Does anyone know how many generations epigenetic changes can last for? Is there a known limit, especially in mammals?
 
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windy miller said:
Does anyone know how many generations epigenetic changes can last for? Is there a known limit, especially in mammals?
In mammals: 1 generation - and more commonly zero.
Here is an excerpt from a Life Sciences article:
https://www.livescience.com/37703-epigenetics.html
Epigenetic inheritance

It may be possible to pass down epigenetic changes to future generations if the changes occur in sperm or egg cells. Most epigenetic changes that occur in sperm and egg cells get erased when the two combine to form a fertilized egg, in a process called "reprogramming." This reprogramming allows the cells of the fetus to "start from scratch" and make their own epigenetic changes. But scientists think some of the epigenetic changes in parents' sperm and egg cells may avoid the reprogramming process, and make it through to the next generation. If this is true, things like the food a person eats before they conceive could affect their future child. However, this has not been proven in people.

The National Center for Biotechnology Information has a good article on this:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020004/

Here is the abstract:
Since the human genome was sequenced, the term “epigenetics” is increasingly being associated with the hope that we are more than just the sum of our genes. Might what we eat, the air we breathe, or even the emotions we feel, influence not only our genes but those of descendents? The environment can certainly influence gene expression, and can lead to disease, but trans-generational consequences are another matter. While the inheritance of epigenetic characters can certainly occur - particularly in plants – how much is due to the environment and the extent to which it happens in humans, remains unclear.
 
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Related to Epigenetic changes , how many generations does it last?

What are epigenetic changes?

Epigenetic changes refer to alterations in gene expression that occur without changes to the underlying DNA sequence. These changes can be influenced by environmental factors and can impact the way genes are turned on or off, ultimately affecting an individual's traits and health.

How are epigenetic changes inherited?

Epigenetic changes can be inherited through both maternal and paternal lineages. However, the exact mechanisms of epigenetic inheritance are still being studied and understood. It is thought that certain epigenetic marks can be passed down from parents to offspring, but the extent to which this occurs and how long these changes last is still being investigated.

How long do epigenetic changes last?

The duration of epigenetic changes can vary depending on the type of change and the individual's environment. Some changes may be short-lived and only last for a few generations, while others may persist for many generations. It is also possible for epigenetic changes to be reversed or modified through certain interventions or lifestyle choices.

Can epigenetic changes be reversed?

Yes, some epigenetic changes can be reversed through certain interventions such as diet and exercise. Additionally, some medications have been shown to alter epigenetic marks and potentially reverse changes associated with certain diseases. However, more research is needed to fully understand the extent to which epigenetic changes can be reversed.

Can epigenetic changes be passed down to future generations?

Yes, some epigenetic changes can be passed down to future generations. However, the degree to which this occurs and the impact it has on the offspring is still being studied. It is also important to note that epigenetic changes can be influenced by the individual's environment and lifestyle choices, which can further complicate the inheritance of these changes.

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