If we apply a double-angle identity for cosine on the numerator of the integrand, we find:
$$\cos(4x)-\cos(4\alpha)=\left(2\cos^2(2x)-1 \right)-\left(2\cos^2(\alpha)-1 \right)=$$
$$2\left(\cos(2x)+\cos(2\alpha) \right)\left(\cos(2x)-\cos(2\alpha) \right)$$
Applying a double-angle identity for cosine again, we have:
$$4\left(\cos(2x)+\cos(2\alpha) \right)\left(\cos(x)+\cos(\alpha) \right)\left(\cos(x)-\cos(\alpha) \right)$$
Hence, the definite integral may now be written:
$$I=4\int_0^{\pi}\left(\cos(2x)+\cos(2\alpha) \right)\left(\cos(x)+\cos(\alpha) \right)\,dx$$
Using the property $$\int_0^a f(x)\,dx=\int_0^a f(a-x)\,dx$$ we also have:
$$I=4\int_0^{\pi}\left(\cos(2x)+\cos(2\alpha) \right)\left(-\cos(x)+\cos(\alpha) \right)\,dx$$
Adding the two expressions for $I$, we obtain:
$$2I=8\cos(\alpha)\int_0^{\pi}\cos(2x)+\cos(2\alpha)\,dx$$
Hence:
$$I=4\pi\cos(\alpha)\cos(2\alpha)$$
Adrian, glad to see we obtained the same result! :D