To express the differential equation (dy/dx) = (y/x) + tan(y/x) in the form Mdx + Ndy = 0, one approach is to set M = (y/x) + tan(y/x) and N = -1. This transformation allows for the equation to be rearranged into the desired format. The discussion emphasizes the importance of correctly identifying M and N as functions of x and y. The proposed solution simplifies the equation while maintaining its integrity. Understanding these transformations is crucial for solving differential equations effectively.