The study published in the journal Microbiome by scientists from the Quadram Institute demonstrates that fecal transplants between young and aging mice can significantly alter aging markers. Transferring gut microbes from aged mice to young mice resulted in a loss of gut lining integrity, leading to increased inflammation in the brain and eyes. This research highlights the critical role of microbiota in aging and its potential implications for therapeutic interventions.
PREREQUISITESResearchers in microbiome studies, healthcare professionals interested in aging, and anyone exploring innovative treatments for age-related inflammatory conditions.
"To better understand the effects of these changes in the microbiota in old age, scientists from the Quadram Institute transferred the gut microbes from aged mice into healthy young mice, and vice versa. They then looked at how this affected inflammatory hallmarks of aging in the gut, brain and eye, which suffer from declining function in later life.
The study, published in the journal Microbiome, found that the microbiota from old donors led to loss of integrity of the lining of the gut, allowing bacterial products to cross into the circulation, which results in triggering the immune system and inflammation in the brain and eyes."