To find critical numbers, take the derivative of the function, set it equal to zero, and solve for x. For example, for the function y = x^2 + x, the derivative y' = 2x + 1 leads to the critical number x = -1/2 when set to zero. Critical points occur where the derivative is zero or undefined, while points of inflection are determined by changes in the second derivative. An example illustrates that for f(x) = x^3 - 3x, the critical point is at x = 1, and the inflection point is at x = 0. Understanding these concepts is essential for analyzing the maxima and minima of functions.