JohnH said:
I understand second quantization is applied to the Lagrangian formalism. What I don't understand is why it can't be applied to the Nielsen form if it is interchangeable with the Euler-Lagrange equation.
The problem with a point-particle picture is that there is no Hamiltonian formalism for relativistic interacting point particles and thus it's also impossible to use some heuristic argument like "canonical quantization" to formulate a relativistic quantum mechanics, and indeed it turns out that except for free particles there is no way to formulate a first-quantization formalism.
The physical reason is also obvious today: Whenever you deal with particles interacting at "relativistic energies", i.e., if the collision energy gets at or above the mass threshold for the lightest particles which participate in the interactions the scattering particles are involved in, with some probability it's possible that these new particles get created and/or the original particles get destroyed. That means you need a formalism, where creation and annihilation processes of particles can be described.
Historically the first formalism was Dirac's hole-theoretical formulation of QED. That's a very cumbersome way, but at least formally it's equivalent to the modern formalism: Dirac ad hoc introduced the idea that all states referring to negative-frequency modes of the free Dirac equation are occupied, and he defined that to be the vacuum, and thus these filled states only manifistate themselves if at some relativistic reaction an electron out of this "Dirac sea" is excited to the positive-frequency domain, and the corresponding hole acts like a particle with the opposite charge of the electron and positive energy. All this works, afaik, at least for QED, but it's very cumbersome to work with.
Much more adequate and elegant is the use of quantum field theory, i.e., "second quantization". This was already clear in the very beginning of quantum mechanics, when Jordan introduced the idea of quantizing the electromagnetic field in 1926 (in the famous "Dreimännerarbeit"), but at this time most of the other physicists didn't like this idea too much, and that's why a few years later Dirac had to reinvent the idea to describe spontaneous emission of photons in addition to induced emission and absorption, which can also be treated in the semiclassical approximation, where the particles ("electrons") are quantized but the em. field kept classical.
Today relativistic QT is exclusively treated in terms of relativistic, local QFTs, where annihilation and creation processes are very naturally described.