How do pain relieving pills like advil relieve pain?

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Discussion Overview

The discussion revolves around the mechanisms by which pain-relieving pills, specifically ibuprofen (Advil), alleviate pain. Participants explore the role of inflammation, the action of ibuprofen as a non-steroidal anti-inflammatory drug (NSAID), and comparisons with other pain relievers like aspirin. The conversation includes both theoretical and practical aspects of pain relief.

Discussion Character

  • Exploratory
  • Technical explanation
  • Conceptual clarification
  • Debate/contested
  • Mathematical reasoning

Main Points Raised

  • One participant suggests that ibuprofen reduces pain by preventing inflammation, citing personal experience with pain following an injury.
  • Another participant explains that ibuprofen inhibits the formation of prostaglandins, which may reduce longer-lasting pain from injuries but not the initial sharp pain.
  • A question is raised about whether aspirin functions as an anesthetic, prompting clarification that it inhibits cyclooxygenase, similar to ibuprofen.
  • Participants differentiate between anesthetics and analgesics, noting that analgesics relieve pain while anesthetics block sensation entirely.
  • One participant asserts that pain relievers operate by blocking brain receptors or messenger transmission from the source of pain, presenting this as a definitive statement.

Areas of Agreement / Disagreement

Participants express differing views on the mechanisms of pain relief and the distinctions between types of pain relievers. There is no consensus on the exact workings of ibuprofen or the comparison with other medications like aspirin.

Contextual Notes

Some claims about the mechanisms of action are based on personal interpretations and may depend on specific definitions of pain types and drug classifications. The discussion does not resolve the complexities of pain relief mechanisms.

Who May Find This Useful

This discussion may be of interest to individuals seeking to understand the pharmacological effects of pain relievers, particularly in relation to inflammation and pain perception.

bluemoonKY
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On the part of the label where it lists the active ingredients in Advil, it says "Ibuprofen". And it says that ibuprofen is a "non-steroidal anti-inflammatory drug." This makes me think that ibuprofen reduces pain by reducing/preventing inflammation (swelling) somehow. I can see how that would work for a muscular ache. One time someone punched me in the back, and it did not hurt right when they punched me. But a few hours later I was in agony. This made me think that it wasn't the force of the blow per se that caused my pain. It was the swelling as a result of the blow that caused me pain. The swelling was caused by white blood cells rushing to the area to repair the damage.

Is my supposition that Advil works by reducing/preventing swelling correct?

Would Advil reduce the pain from a cut? Say if someone cut their finger accidentally on a saw, would advil reduce the pain from the cut?
 
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Ibuprofen inhibits the formation of prostaglandin - it should have some effect on the "achey" type pain from physical injury. It is not an anaesthetic, so you still get the sharp pains... i.e. you cut your finger, you'll feel the initial pain, but the longer-lasting pain should be reduced depending on how much you took.

refs:
http://www.sharecare.com/health/nonsteroidal-anti-inflammatory-drugs/how-ibuprofen-relieve-pain
http://www.webmd.com/drug-medication/otc-pain-relief-10/pain-relievers-nsaids

Google is your friend here.
 
Is aspirin an anesthetic?
 
No aspirin works by inhibiting cyclooxygenase which is required for the formation of prostaglandins, as Simon mentioned above. Just to re-iterate, Google really is your friend here. There is a ton of information out there about NSAIDs.

Anesthetics typically have -caine endings in there names (lidocaine, procaine etc) as they are derivatives or tweaked versions of cocaine, which is itself a local anesthetic.
 
Yeah, part of the appeal of cocain is that it provides a (usually temporary) end to the heartache, and the thousand natural shocks that flesh is heir to.

Anyway - the way to tell the difference between an anaesthetic and an analgesic is to see if it stops you from feeling it when you prick your finger. Analesics, like asperin, paracetamol, ibuprofin, all releive pain - while anaesthetics like novocain, remove or deaden all sensation.

But please - this is also something you can google very easily.
The way to get the best out of sites like this one is to go look up the facts and definitions you seek then ask about the bits you don't understand.
 
Pain relievers work in one of two ways, they either block receptors in the brain, or messenger transmission from the source. There is no alternative.
 

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