How genetically distinct are mice from rats?

[Simfish]

As compared, to say, how genetically distinct are humans from rhesus macaques?

There are some chemicals that are REALLY toxic for mice but not for rats (paracetamol is an example). We can't obtain definite predictions, but knowing this, maybe we might be able to make a rough guessestimation of the percent of chemicals whose effects on macaques are different than those on humans.

 

[jsgruszynski]

As compared, to say, how genetically distinct are humans from rhesus macaques?

There are some chemicals that are REALLY toxic for mice but not for rats (paracetamol is an example). We can't obtain definite predictions, but knowing this, maybe we might be able to make a rough guessestimation of the percent of chemicals whose effects on macaques are different than those on humans.

Rat and mouse genomes are available online. One option would be to use various open source and free tools to find out directly.

http://genome.cshlp.org/content/14/4/685.full" seems to be one that looks into this (can't say much about it other than I found it with a 5-second Google search of "rat mouse genome"