The discussion focuses on estimating the number of prime numbers between 10^100 and 10^101. A suggested method involves using the logarithmic integral function, Li(x), which approximates the number of primes up to a given number x. By calculating Li(10^101) and Li(10^100) and subtracting the two results, one can obtain a reliable estimate for the number of primes in that range. The mention of Riemann's work implies there may be more recent advancements in prime number estimation, but Gauss's formula remains a valid approach. This method provides a practical way to estimate primes in large numerical ranges.