How would weight distribution affect wheel performance on a vehicle?

[Gird.]

I am trying to find the answer to the below question if anyone could please help:

How would the wheel on a vehicle react if the weight distribution was altered - ie, if one spoke was larger and therefore heavier than the rest? What would the likely implications be?

 

[Lok]

Wheels get centered usually, by applying weights (1-10g) to the rim. If not at high speed you feel a vibration which with a bit of harmonical luck can be quite powerful, and can cause loss in traction.