The discussion focuses on understanding the computation of new bounds during a u-substitution in integration. Participants clarify that the inequalities represent the range of integration, and the bounds can be derived by substituting the limits of the x-integral into the u-expression. It is emphasized that the variables u and x are interchangeable as they are dummy variables in integration. The confusion regarding substituting inequalities is addressed by explaining that only the endpoint values should be substituted into the equation for u. Ultimately, the participants conclude that the process is straightforward once the correct approach is understood.