In physics, the integration constant is used when evaluating indefinite integrals, while it is not needed for definite integrals. When solving problems, initial conditions such as initial velocity or position help determine the value of the integration constant. Often, these initial values are set for convenience, such as being equal to zero or one. Understanding the context of the problem is crucial for identifying whether to include the integration constant. Properly applying these concepts ensures accurate solutions in physics problems involving integration.