Calculating the inverse sine without using sin-1 can be approached using alternative methods like the arctan function and trigonometric identities. The discussion highlights that sine and cosine functions are not one-to-one, leading to potential quadrant issues when determining angles. A suggested method involves using the relationship arcsin(x) = arctan(x / sqrt(1 - x * x)), which derives from the properties of a right triangle. Additionally, the Taylor series expansion for arcsin is mentioned as another way to compute the value, although its application for angle calculation is questioned. Overall, understanding the quadrant and employing these alternative methods can help resolve issues with inverse sine calculations.