Is Sars-Cov2 cytolytic or cytopathic?

[mktsgm]

TL;DR Summary

Is the current Covid-19 caused by Sars-cov2 virus is theresult of cytolytic effects or cytopathic effects of the virus?

We know viral infections result in cellular damage while they're replicating in the host cells.. Damage can be cytolytic or cytopathic.

I want to know how Sars-cov2 causes such damage? Is it cytopathic or cytolytic? Do they (viruses) kill the host cells or just damage them?

 

[jim mcnamara]

Sometimes when you try to classify something it is not helpful. People feel better when they can assign a classification to some phenomenon. But that does not mean it creates a real understanding. I think this applies here.

A short really simplified answer to what is happening involves ACE2 receptors. Then subsequent oxidative stress. This triggers clotting, all in the context inflammation, a "cytokine storm", arterial blockage, and ultimately destruction of alveoli (sacs) in the lungs, all of which then causes the patient to die from lack oxygen uptake.

Actually this description is almost a disservice. Too high level. I've gone through 8 hours of medical lectures to get a partial understanding. To make matters worse, our current understanding not complete.

So in terms of your classification question: both are true. Which is not helpful, IMO.
Cells are killed and burst by the virus takeover of the cell. Bad. Worse: that cell death causes horrible subsequent other cell pathology by preventing regulating proteins from forming - ex., Angiotensin 1,7 is one.

 

[mktsgm]

Thank you Jim. Clear as crystal. This is what I wanted.