Whenever two electric charges get very close together, virtual positrons and electrons are created in the Coulomb field. This is known as vacuum polarization, and is part of charge renormalization. In high energy electron-electron or electron-positron collisions, there is more than enough energy to create real electron positron pairs. SLAC has created 1-miiliamp positron beams using pair production. SLAC has even created electron-positron pairs by shooting a laser at an electron beam, which gamma-boosts the laser photons by a factor of about gamma-squared.
[added] Early experiments that first verified(?) the quantum nature of the photon included the photoelectric effect, and also about the transverse electric field (by polarization of the electron recoil), and later by verification of the theoretical prediction of the cross-section and magnitude of polarization effects in Compton scattering, bremsstrahlung, pair production, etc.. For a thorough review, read Heitler's book on the Quantum Theory of Radiation.
Bob S