Is there vaccine non-effectiveness?

[icakeov]

Hello, is there such a thing as a vaccine “not having any effect” on a person, and for some reason making it a “dud” for that specific person?

I guess if the dose isn’t strong enough that could be the case, but is there such a thing of the person not “reacting” to those antibodies for some reason, or rejecting them? Or some other reason why a vaccine "wouldn't work" on a specific person.

 

[jim mcnamara]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962729/Abstract

There are 2 major factors responsible for vaccine failures, the first is vaccine-related such as failures in vaccine attenuation, vaccination regimes or administration. The other is host-related, of which host genetics, immune status, age, health or nutritional status can be associated with primary or secondary vaccine failures. The first describes the inability to respond to primary vaccination, the latter is characterized by a loss of protection after initial effectiveness. Our studies concentrate on the evaluation of immunological characteristics responsible for primary vaccine failures in different (risk) populations for which the underlying mechanisms are currently unknown. Here we summarise current knowledge and findings from our studies...

Note that "type 2" failure has components - failure to immunize, failure to maintain resistance.
Elderly populations normally require greater doses of influenza vaccine, a kind of failure to immunize.

 

[BillTre]

Yes, this does happen.
I have had a Hepatitis B vaccine that I did not produce antibodies to.
I should repeat it.

 

[icakeov]

Many thanks!