In Mathematica, creating "M" levels of nested loops, where each loop runs from 1 to specific counts (N_1, N_2, ..., N_M), can be efficiently achieved using a single loop that calculates indices based on a single index. The formula for calculating the indices involves modular arithmetic to determine the values of i_1, i_2, ..., i_M during each iteration. An alternative method involves incrementing the first index and resetting it when it exceeds its limit, while incrementing the next index, which can streamline the process. Additionally, examples of both recursive and iterative implementations of factorial functions in Mathematica illustrate different coding approaches, emphasizing the educational value of understanding both methods. The discussion also highlights the importance of mastering recursion, especially for those who find it challenging, and provides resources for further exploration of factorial implementations across various programming languages.