Are There Exceptions to Transcription Factors Binding to Specific DNA Sequences?

[MrGenetic]

Can be possible the transcription factor's dna binding domain's binding to two or more different DNA sequence in different(or also same) enhancers? Or there is no exception, it must be specific for dna sequence like CAATTAGTCA...
for example my book says; ''MITF's binding domain can attach just the one dna sequence in the different specific enhancers regions. Is there any different possibility?

 

[Ygggdrasil]

Part of the answer is tautological: transcription factors are defined as proteins that bind to DNA in a sequence-specific manner. Therefore, if a protein does not bind to a specific DNA sequence, it will not be classified as a transcription factor. There are plenty of transcriptional regulators that do not bind specific DNA sequences (e.g. chromatin remodeling proteins, RNA polymerase and many of its associated factors, the polycomb repressive complexes, etc), and some are recruited to DNA by features of the than DNA sequence (e.g. histone modifications).

For most sequence-specific DNA binding proteins, I think most will recognize only a certain DNA sequence. I found an example of a transcription factor that can recognize two distinct DNA sequences, but this is because the TF has two distinct DNA-binding domains (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1171765/).