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Blenton
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What is the mechanism by which they adhere to each other, and what stops them from sticking together when say you put your hands together?
Mechanism by which cells adhere to each other
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SUMMARY
The mechanism by which cells adhere to each other involves various types of junctions, including tight junctions mediated by occludins and claudins, gap junctions formed by connexins, and cell-cell adhesion molecules known as cadherins. Additionally, integrins facilitate attachment to the basal lamina. These junctions are highly regulated, ensuring that cells do not stick together excessively, such as when hands are pressed together. The outer layer of skin consists of keratinized dead cells, which further illustrates the complexity of cellular adhesion and regulation.
PREREQUISITES- Understanding of cell junction types: tight junctions, gap junctions, and adherens junctions
- Familiarity with proteins involved in cell adhesion: occludins, claudins, connexins, cadherins, and integrins
- Basic knowledge of skin structure and function
- Insight into cellular regulation mechanisms
- Research the role of occludins and claudins in tight junction formation
- Study the function of connexins in gap junctions
- Explore the significance of cadherins in cell-cell adhesion
- Investigate the regulatory mechanisms governing integrin function
Cell biologists, biomedical researchers, and students studying cellular adhesion mechanisms and skin biology will benefit from this discussion.
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