Memory B and T Cells: How Many and How Long?

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SUMMARY

This discussion focuses on the longevity and quantity of memory B and T cells in response to specific antigens, particularly referencing the smallpox vaccine. Research indicates that memory B cells specific to the smallpox vaccine can persist for over 50 years in immunized individuals, maintaining a stable frequency of 0.1% of total circulating IgG+ B cells. In contrast, T cells related to vaccinations, such as tetanus, may require boosters approximately every 10 years due to their shorter lifespan. The findings underscore the durability of memory B cells and their capability to mount an effective immune response upon re-exposure.

PREREQUISITES
  • Understanding of immunology concepts, particularly memory B and T cells.
  • Familiarity with vaccination protocols and their implications on immune memory.
  • Knowledge of antibody responses and immunological memory.
  • Access to immunological research studies and literature.
NEXT STEPS
  • Review the study on memory B cells from the Journal of Immunology for detailed insights.
  • Investigate the mechanisms of anamnestic antibody responses in immunized individuals.
  • Explore the differences in longevity between memory B cells and memory T cells.
  • Learn about the implications of booster vaccinations on long-term immunity.
USEFUL FOR

This discussion is beneficial for immunologists, healthcare professionals, vaccine researchers, and anyone interested in the dynamics of immune memory and vaccination strategies.

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I've learned about memory B and T cells. I'm wondering how many of each a person has for a specific antigen? How long do they live?
 
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I don't know the exact numbers, but when you look at tetanus vaccinations you need to get a booster after 10 years. So they can live up to ten years.

Here a study who looked at it in detail: http://www.jimmunol.org/cgi/content/full/171/10/4969#F1
In this study, we demonstrate that smallpox vaccine-specific memory B cells last for >50 years in immunized individuals. Virus-specific memory B cells initially declined postimmunization, but then reached a plateau 10-fold lower than peak and were stably maintained for >50 years after vaccination at a frequency of 0.1% of total circulating IgG+ B cells. These persisting memory B cells were functional and able to mount a robust anamnestic Ab response upon revaccination.
 

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