Mice and Yeast Lifespans: Does SCH9 + SIR2 Knockout Increase Longevity?

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bioquest
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Does knocking out SCH9 and SIR2 in mice increase their lifespans by 6 times? Longo said age-dependent mutations increase at a remarkably low pace in organisms lacking both SCH( and SIR2 but does that apply to mice as well as yeast?
 
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Would there be downsides to organisms having their cells live 6 times longer? what would the downsides be, I mean would they die from there being too many cells?
 
yah but theve also been able to extend the life of human cells, like liver cells through that so it might not apply to just lower life forms such as yeast