Mice and Yeast Lifespans: Does SCH9 + SIR2 Knockout Increase Longevity?

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Discussion Overview

The discussion revolves around the potential impact of knocking out the SCH9 and SIR2 genes on the lifespan of mice, drawing parallels to findings in yeast. Participants explore the implications of such genetic modifications on longevity and the associated biological consequences.

Discussion Character

  • Exploratory, Debate/contested, Conceptual clarification

Main Points Raised

  • One participant questions whether knocking out SCH9 and SIR2 in mice could lead to a sixfold increase in lifespan, referencing claims made by Longo regarding age-dependent mutations in organisms lacking these genes.
  • Another participant raises concerns about potential downsides of significantly extended lifespans, specifically questioning whether an increase in cell longevity could lead to issues such as overcrowding of cells.
  • A participant shares a link to a study suggesting a new technique that multiplies lifespan in simple organisms, implying relevance to the discussion.
  • Another participant notes that similar techniques have been used to extend the lifespan of human cells, suggesting that the findings may not be limited to simpler organisms like yeast.

Areas of Agreement / Disagreement

Participants express differing views on the implications of gene knockouts for lifespan extension, with some focusing on potential benefits while others highlight possible negative consequences. The discussion remains unresolved regarding the overall impact of these genetic modifications.

Contextual Notes

Participants do not clarify the specific mechanisms by which SCH9 and SIR2 influence lifespan, nor do they address the assumptions underlying the proposed lifespan increases. The applicability of findings from yeast to mice is also not definitively established.

Who May Find This Useful

Researchers and enthusiasts in genetics, aging, and cellular biology may find this discussion relevant, particularly those interested in the genetic factors influencing lifespan across different organisms.

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Does knocking out SCH9 and SIR2 in mice increase their lifespans by 6 times? Longo said age-dependent mutations increase at a remarkably low pace in organisms lacking both SCH( and SIR2 but does that apply to mice as well as yeast?
 
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Would there be downsides to organisms having their cells live 6 times longer? what would the downsides be, I mean would they die from there being too many cells?
 
Is this what's prompting these questions
http://www.bio-medicine.org/biology-news/New-technique-multiplies-life-span-in-simple-organisms-1883-1/
 
yah but theve also been able to extend the life of human cells, like liver cells through that so it might not apply to just lower life forms such as yeast
 

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