How Does Differential Equations Model Drug Distribution in the Bloodstream?

  • Thread starter Thread starter badtwistoffate
  • Start date Start date
  • Tags Tags
    Mixing
Click For Summary
SUMMARY

The discussion focuses on modeling drug distribution in the bloodstream using differential equations. The specific scenario involves a drug concentration of 5 mg/cm³ entering the bloodstream at a rate of 100 cm³/hr, with an absorption rate constant of 0.4 hr⁻¹. The differential equation derived is dD/dt = 500 - D/0.4, where D(t) represents the amount of drug absorbed by the body over time. Participants confirm that separation of variables is a valid method for solving this linear differential equation with constant coefficients.

PREREQUISITES
  • Understanding of differential equations, specifically linear differential equations with constant coefficients.
  • Knowledge of drug pharmacokinetics, including absorption and elimination rates.
  • Familiarity with separation of variables as a mathematical technique.
  • Basic concepts of drug concentration and flow rates in pharmacology.
NEXT STEPS
  • Study the application of linear differential equations in pharmacokinetics.
  • Learn about the method of separation of variables in solving differential equations.
  • Explore the impact of varying absorption rates on drug distribution models.
  • Investigate numerical methods for solving differential equations in real-world scenarios.
USEFUL FOR

Pharmacologists, biomedical engineers, and students studying pharmacokinetics or differential equations in biological systems will benefit from this discussion.

badtwistoffate
Messages
81
Reaction score
0
fluid with 5mg/cm^3 of drug enters bloodsteam at 100cm^3/hr, drug is absorbed by body tissue or otherwise leaves the bloodstream at a rate proportional to the amount present with a rate constant of .4(hr)^-1.

so assuming the drug is always uniformly distrbuted throughout the bloodstream, the differential equation for the amount of the drug that is present at time t is:

What i have done is:
let D(T)=amnt of drug absorbned by the body, at time t (hrs), in mg

so i got dD/dt= rate in - rate out

i have the rate in=100(5) mg/cm^3 or 500 mg/cm^3
and rate out= D(t)/.4

so my equation is dD/dt= 500-D/.4 then i can just you separation of varibles...

what do you all think
 
Physics news on Phys.org
Yes, separation of variables will work. You might also note that that is a "linear differential equation with constant coefficients". Either method will work.
 
Question: A clock's minute hand has length 4 and its hour hand has length 3. What is the distance between the tips at the moment when it is increasing most rapidly?(Putnam Exam Question) Answer: Making assumption that both the hands moves at constant angular velocities, the answer is ## \sqrt{7} .## But don't you think this assumption is somewhat doubtful and wrong?

Similar threads

  • · Replies 2 ·
Replies
2
Views
9K
  • · Replies 7 ·
Replies
7
Views
2K
  • · Replies 15 ·
Replies
15
Views
8K
  • · Replies 4 ·
Replies
4
Views
3K
  • · Replies 2 ·
Replies
2
Views
2K
  • · Replies 4 ·
Replies
4
Views
3K
  • · Replies 4 ·
Replies
4
Views
5K
  • · Replies 12 ·
Replies
12
Views
2K
  • · Replies 2 ·
Replies
2
Views
2K
  • · Replies 9 ·
Replies
9
Views
4K