Moderna Booster Effective for at least 6 Months against Omicron

[Tom.G]

"Seven months after the second dose was administered (before the booster), neutralization of the omicron variant was detected in only 55% of the participants, and the ID50 geometric mean titers were 8.4 times lower than those against the D614G variant (Figure 1A). A booster dose of 50 μg of the mRNA-1273 vaccine, which is currently approved under Emergency Use Authorization for adults who are 18 years of age or older, was associated with ID50 geometric mean titers against the omicron variant that were 20.0 times higher than those assessed 1 month after the second vaccination; these titers were 2.9 times lower than those against the D614G variant."


Synopsis:
https://www.nejm.org/doi/full/10.1056/NEJMc2119912

Full article:
https://www.nejm.org/doi/full/10.1056/NEJMoa2116414?query=recirc_curatedRelated_article

 

[Greg Bernhardt]

It looks like the Moderna mRNA-1273 vaccine is able to protect against the omicron variant, but not as effectively as it does against the D614G variant. After 7 months, only 55% of the participants had neutralization of the omicron variant, and their ID50 geometric mean titers were 8.4 times lower than those against the D614G variant. However, after a booster dose of 50 μg of the vaccine, the ID50 geometric mean titers against the omicron variant increased 20.0 times, though they were still 2.9 times lower than those against the D614G variant. This is an interesting finding, and I'm looking forward to seeing more research on this topic.