1. The problem statement, all variables and given/known data [tex]\Delta[/tex]9-Tetrahydrocannabinol (THC) is the primary psychoactive constituent of marijuana. Its metabolites include 11-hydroxy- [tex]\Delta[/tex]9-THC (11-OH-THC) and 11-nor-9-carboxy- [tex]\Delta[/tex]9-THC (THC-COOH). 1)Write down the molecular structure of these three compounds. 2)Develop an analytical method to determine ng/mL levels of THC, 11-OH-THC and THC-COOH in urine samples, which include: a)step-by-step sample preparation b)instrumentation c)calibration method Please provide your reasoning for choosing a specific method or instrument. 2. Relevant equations 3. The attempt at a solution Well, I looked up the structure of THC, but as for the notation used for the description of the structure, I'm not sure what they all mean. It's been awhile since I took organic... Anyway, for the structures, Is it correct to say that it's the ones I found in the links? 1) THC structure: http://en.wikipedia.org/wiki/Tetrahydrocannabinol" [Broken] 11-hydroxy- [tex]\Delta[/tex]9-THC (11-OH-THC) : http://en.wikipedia.org/wiki/11-Hydroxy-THC 11-nor-9-carboxy- [tex]\Delta[/tex]9-THC (THC-COOH) : http://en.wikipedia.org/wiki/11-nor-9-Carboxy-THC" [Broken] What does the, "nor" and the [tex]\Delta[/tex] stand for in the notations? 2) I guess I can look up the steps and such, but with calibration, how would that work? Would there be an external standard for the instrument (LC-MS or other instrument) In addition I hear about derivatization of samples prior to analysis for this in some papers. What is derivatization and why is it needed here? Thank you and the last question I bolded is something I need help on.