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Mouse oocytes made from stem cells

  1. Oct 17, 2016 #1

    Ygggdrasil

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    Published today in Nature:
    http://www.sciencemag.org/news/2016/10/mouse-egg-cells-made-entirely-lab-give-rise-healthy-offspring

    Citation: Hikabe et al. 2016. Reconstitution in vitro of the entire cycle of the mouse female germ line. Nature. Published online Oct 17 2016. http://dx.doi.org/10.1038/nature20104 [Broken]

    Abstract:
     
    Last edited by a moderator: May 8, 2017
  2. jcsd
  3. Oct 18, 2016 #2
    Why such low success rate? What will increase it?
     
  4. Oct 18, 2016 #3

    Ygggdrasil

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    If I knew the answer to that, I would publish it in Nature :)

    It's likely that the researchers don't fully understand all of the factor required for the development and maturation of oocytes. There are likely factors present in the cellular environment that the researchers cannot fully recapitulate in a test tube. These could be growth factors/signaling molecules that are lacking or it could involve mechanical contact with specific types of cells. They are getting close enough that a small fraction can overcome the lack of those factors by chance, but to improve the efficiency would require identifying the missing factors.
     
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