Insulin & Glucagon: Negative Feedback for Blood Sugar

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SUMMARY

The discussion centers on the role of insulin and glucagon in regulating blood sugar levels through negative feedback mechanisms. Insulin, secreted by the pancreas, facilitates the absorption of sugars from the bloodstream, while glucagon acts to increase blood sugar levels when necessary. This interplay ensures homeostasis; when blood sugar levels are adequate, insulin production decreases, signaling the pancreas to reduce further secretion. In diabetic patients, this regulatory mechanism may be impaired, leading to improper insulin production and glucose management.

PREREQUISITES
  • Understanding of hormonal functions, specifically insulin and glucagon
  • Knowledge of the pancreas and its role in glucose metabolism
  • Familiarity with the concept of homeostasis in biological systems
  • Basic understanding of diabetes and its impact on insulin regulation
NEXT STEPS
  • Research the mechanisms of insulin signaling pathways
  • Study glucagon's role in glucose homeostasis and its effects on liver function
  • Explore the physiological differences between Type 1 and Type 2 diabetes
  • Learn about the impact of diet on insulin sensitivity and blood sugar levels
USEFUL FOR

Biologists, healthcare professionals, students studying endocrinology, and individuals interested in diabetes management and metabolic health.

JimmyRay
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Hi, I want to know how the Insulin/Glucagon hormones act as negative feedback.

Blood sugar goes up, insulin is created, blood sugar goes down, glucagon is created, blood sugar goes up again, and they basically compete with each other to maintain homeostasis, right? But how is this negative feedback.
 
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Insulin hormone is secreted by Pancreas. Insulin mainly encourages the cells to absorb sugars/carbohydrates from the blood. Pancreas secrete Insulin , but when sugar has been absorbed by the cells in apt. amount , and there is just enuff sugar as needed by the body , the overproduction of Insulin gives a negative feedback to previous reactions , due to which pancreas are no mor stimulated by the brain to produce insulin. But when sugar/CarboH levels are again on the increase , Pancreas are again stimulated to produce Insulin which helps cells absorb the sugar/CarboH . In diabetic patients , it maybe the case ,that cells are not being stimulated properly , or there is no coordination between insulin production and pancrea-stimulation.
 

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