NITRIC OXIDE CARDIO vascular system

[djflush]

any ideas of good papers on this molecule in the cardiovascular system vasodilation etc

 

[jim mcnamara]

Here is one place to start and follow the links for a lot of related papers.

http://www.ncbi.nlm.nih.gov/pubmed/9576114

Is this your idea of a series of good papers? Or did you want a a review paper?

 

[djflush]

well basically I am trying to gain a good understanding of the area using papers.Like i know its an endothelium derived vasodilator. Also that NO upregulates the conversion of GMP to cyclic GMP, and cGMP fuels Protein Kinase G, which phosphorylates...something I forget what, which decreases intracellular calcium. Calcium is what ultimately contracts your smooth muscle, so when intracellular calcium is decreased, you have smooth muscle relaxation.But I am trying to find out more about its purpose in the cardiovascular system while using papers to help explain it.Also if i can find graphs this would be a bonus as it may make some ponits more clear.Any help would be really appreciated.

 

[jim mcnamara]

You need a textbook more than a smattering of papers. I'll look around. Maybe Moonbear or someone else is more current with this area and can suggest something better.