Medical NITRIC OXIDE CARDIO vascular system

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The discussion centers on finding scholarly papers related to a specific molecule involved in vasodilation within the cardiovascular system. The initial reference provided is a link to a PubMed article, which serves as a starting point for exploring related research. The focus is on understanding the role of this endothelium-derived vasodilator, particularly its mechanism involving nitric oxide (NO), cyclic GMP, and Protein Kinase G, which ultimately leads to decreased intracellular calcium and smooth muscle relaxation. There is a suggestion that a comprehensive textbook may be more beneficial for gaining a thorough understanding than just individual papers. The conversation indicates a need for more current recommendations and possibly visual aids like graphs to clarify complex points.
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any ideas of good papers on this molecule in the cardiovascular system vasodilation etc
 
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well basically I am trying to gain a good understanding of the area using papers.Like i know its an endothelium derived vasodilator. Also that NO upregulates the conversion of GMP to cyclic GMP, and cGMP fuels Protein Kinase G, which phosphorylates...something I forget what, which decreases intracellular calcium. Calcium is what ultimately contracts your smooth muscle, so when intracellular calcium is decreased, you have smooth muscle relaxation.But I am trying to find out more about its purpose in the cardiovascular system while using papers to help explain it.Also if i can find graphs this would be a bonus as it may make some ponits more clear.Any help would be really appreciated.
 
You need a textbook more than a smattering of papers. I'll look around. Maybe Moonbear or someone else is more current with this area and can suggest something better.
 

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