Nucleoli and Nucleus: The Relationship and Role in the Nuclear Matrix

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SUMMARY

The discussion centers on the relationship between nucleoli and the nucleus, specifically addressing the lack of a clear membrane around nucleoli and its implications for the nuclear matrix. It is established that nucleoli utilize physical mechanisms resembling phase separation to maintain their distinct structure within the nucleoplasm. Recent research has significantly advanced understanding in this area, highlighting the dynamic nature of nucleoli and their interaction with the nuclear matrix.

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  • Understanding of nuclear biology and cellular structures
  • Familiarity with phase separation concepts in biological systems
  • Knowledge of nucleoplasm composition and function
  • Awareness of recent advancements in molecular biology research
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  • Research the mechanisms of phase separation in cellular structures
  • Explore recent reviews on nucleoli and nuclear matrix interactions
  • Investigate the role of nucleoli in ribosome biogenesis
  • Study the implications of nucleolar dynamics on gene expression
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Cell biologists, molecular biologists, and researchers interested in nuclear structure and function, particularly those focusing on nucleoli and their role in cellular processes.

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If nucleoli does not have a clear membrane,wouldn't it get mixed up with substances in the nuclear matrix present in the nucleus ?
 
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The nucleolus is though to separate itself from the rest of the nucleoplasm via physical mechanisms resembling phase separation (like how oil droplets can separate from water). This is a very active area of research with many new results in the past couple of years. Here's a recent review on the topic: http://www.sciencedirect.com/science/article/pii/S0955067415000435
 
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Ygggdrasil said:
phase separation (like how oil droplets can separate from water).
That's the perfect answer.Thank you :smile:
 

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