Phase I of clinical HIV vaccine trial successful

  1. Pythagorean

    Pythagorean 4,609
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    note: Phase I is just safety testing, not efficacy. Still exciting, though!

    http://communications.uwo.ca/media/...i_clinical_trial_of_sumagen_aids_vaccine.html
     
    1 person likes this.
  2. jcsd
  3. Greg Bernhardt

    Staff: Admin

    This is great news!
     
  4. Monique

    Monique 4,700
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    Let's just call it HIV vaccine, AIDS is the final stage of HIV infection.
    How do they deal with the many strains of HIV and mutation frequency?
     
  5. Ryan_m_b

    Staff: Mentor

    Fixed.
     
  6. Pythagorean

    Pythagorean 4,609
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    Not sure, I haven't read it. The molecular biology would probably be over my head.
     
  7. Monique

    Monique 4,700
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    People are already stating that this is a medical breakthrough, while clearly a phase II study must still be conduced to show that the vaccine is effective.

    I mean, there is a vaccine against the influenza virus, but it doesn't mean that no-one gets the flu anymore. Even people who are vaccinated can get sick.
     
  8. Pythagorean

    Pythagorean 4,609
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    Is any vaccine 100% effective? I don't think that's the expectation.

    Anyway, this isn't the first HIV vaccine developed. I don't know what ever happened to the MVA-B vaccine that supposedly had a 90% success rate (and only at reducing HIV to a minor infection, not curing it) in initial trials.

    http://www.foxnews.com/health/2011/09/29/new-vaccine-could-turn-hiv-into-minor-infection/
     
  9. Monique

    Monique 4,700
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    The press release states "Sumagen anticipates not only having the first HIV vaccine in market but also the eradication of HIV/AIDS for human beings."

    90% sounds surprisingly good, do you have a source for that?
     
  10. Borek

    Staff: Mentor

  11. Pythagorean

    Pythagorean 4,609
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  12. Pythagorean

    Pythagorean 4,609
    Gold Member

  13. Monique

    Monique 4,700
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    Ok so the 90% success rate is based on a positive T-cell response, that indeed is not surprising.

    However, my question is about effectiveness of the vaccine for a person. Take the influenza vaccine as an example, it must also raise a good T-cell response, but only reduces the risk of a person to develop the flu by ~60% (since many strains of the virus exist). I wonder if HIV would be comparable.
     
  14. Pythagorean

    Pythagorean 4,609
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    I wonder, how would you test efficacy anyway? You can't infect people with HIV intentionally and it's not going to cure people that already have it. So do you just dose up a high-risk population with the vaccine and wait and see if average number are lower ten years later or something?
     
  15. Greg Bernhardt

    Staff: Admin

    Another promising HIV vaccine from Oregon Health and Science University
    http://www.gizmag.com/hiv-aids-vaccine-ohsu/29042/

     
  16. Curious3141

    Curious3141 2,970
    Homework Helper

    Basically, yes. Although you don't necessarily have to wait ten years to get useful data out of it. A lot of these studies are done in Africa where high risk populations are studied. It's an ethical minefield, honestly.
     
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