Possible title: Could Tiny Ab8 Antibodies Hold the Key to Curing Covid-19?

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In summary, a paper preprint has been accepted by Cell journal for a study on the high potency of a bivalent human VH domain in SARS-CoV-2 animal models. This study, conducted by Pitt researchers, has found that the Ab8 antibody, similar to previous Coronavirus colds, can prevent and cure Covid-19 in animals. The small size of the Ab8 particles makes it a potential treatment option through nasal spray, with less possibility for side effects as it does not show affinity for human cells. The paper was submitted to Cell in May and just approved this week, suggesting concerns about its content. Further details and information can be provided by @Ygggdrasil, who is knowledgeable in this field.
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jim mcnamara
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TL;DR Summary
Preliminary animal models show very good response to Ab8 as prophylaxis and treatment of Covid-19
Paper preprint- accepted by Cell:
Journal (Pre-proof) High potency of a bivalent human VH domain in SARS-CoV-2 animal models

Wei Li, Alexandra Schäfer, Swarali S. Kulkarni, Xianglei Liu, David R. Martinez,Chuan Chen, Zehua Sun, Sarah R. Leist, Aleksandra Drelich, Liyong Zhang, MarcinL. Ura, Alison Berezuk, Sagar Chittori, Karoline Leopold, Dhiraj Mannar, Shanti S.Srivastava, Xing Zhu, Eric C. Peterson, Chien-Te Tseng, John W. Mellors, DarrylFalzarano, Sriram Subramaniam, Ralph S. Baric, Dimiter S. DimitrovPII:S0092-8674(20)31148-X
DOI: https://doi.org/10.1016/j.cell.2020.09.007

Popular version:
https://scitechdaily.com/ab8-covid-...-completely-neutralizes-the-sars-cov-2-virus/

Pitt researchers who created a similar tiny antibody to previous Coronavirus colds, have been researching something similar for Covid-19.
In animals - mice and hamsters - the Ab8 antibody prevents infection and is effective in curing the disease in progress.

@Ygggdrasil can probably explain the details of these Ab8 antibodies better than I could.
 
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Very interesting and promising. What's the route for prophylactic treatment? Periodic IV infusions? Periodic IM injections? I looked in the popular article, but was not able to find it.
 
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The size of the Ab8 particles is so small that the article mentions the reasonable possibility of a nasal spray, plus Ab8 does not show affinity for human cells - which means less possibility for side effects. All per the article.
 
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The reason I want someone more knowledgeable in this field: The paper was submitted to Cell in May and just approved this week. I thought that Covid-19 articles like this were being fast-tracked, so maybe there were some concerns about the content. @Ygggdrasil , for example, is far more likely to know.
 
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jim mcnamara said:
The size of the Ab8 particles is so small that the article mentions the reasonable possibility of a nasal spray, plus Ab8 does not show affinity for human cells - which means less possibility for side effects. All per the article.
Thanks. Yeah, that is mentioned in the Cell article, but not in the popular article. Very interesting! :smile:
 

1. What are Tiny Ab8 antibodies?

Tiny Ab8 antibodies are small, single-domain antibodies that are derived from llamas. They are able to bind to specific targets, such as viruses or bacteria, and neutralize them.

2. How could Tiny Ab8 antibodies potentially cure Covid-19?

Tiny Ab8 antibodies have shown promising results in laboratory studies, as they have been able to bind to and neutralize the SARS-CoV-2 virus, which causes Covid-19. This means that they could potentially be used as a treatment for the disease.

3. Are Tiny Ab8 antibodies safe for human use?

Yes, Tiny Ab8 antibodies have been shown to be safe for human use in laboratory studies. They are also smaller and simpler than traditional antibodies, which may make them easier to produce and administer.

4. How are Tiny Ab8 antibodies different from traditional antibodies?

Tiny Ab8 antibodies are smaller and simpler than traditional antibodies, as they only consist of a single domain. This makes them easier to produce and may also make them more effective at binding to specific targets.

5. What is the current status of research on Tiny Ab8 antibodies for Covid-19?

Currently, Tiny Ab8 antibodies are still in the early stages of research and have not yet been tested in human clinical trials. However, they have shown promising results in laboratory studies and further research is being conducted to determine their potential as a treatment for Covid-19.

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