Prediction of Solubility using Organic solvents

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SUMMARY

The discussion centers on predicting the solubility of organic substances in various solvents based on their chemical properties. It confirms that the principle of "like dissolves like" is fundamental, allowing for theoretical predictions of solubility by comparing the polarity of stains and solvents. Reference to a liquid chromatography (LC) handbook is essential, as it provides a polarity index for solvents, enabling users to select appropriate solvents based on the nature of the stain (polar or non-polar).

PREREQUISITES
  • Understanding of polarity in organic chemistry
  • Familiarity with liquid chromatography (LC) handbooks
  • Knowledge of common organic solvents such as alcohol, white spirit, and acetone
  • Basic principles of solubility and chemical interactions
NEXT STEPS
  • Research the polarity index of common solvents using an LC handbook
  • Study the chemical structure of various organic stains to determine their polarity
  • Explore advanced solubility prediction models in organic chemistry
  • Learn about the practical applications of solvent selection in stain removal
USEFUL FOR

Chemists, material scientists, and anyone involved in stain removal or solvent selection processes will benefit from this discussion.

boblalux
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Whenever I have a stain (paint, glue etc), I attempt removing it after the following scheme (if unsuccessful, I proceed to the next solvent):
Water, soapy water, alcohol, white spirit, acetone.

My question is...
Is it possible to chemically PREDICT which solvent will be succesqsful on which material/stain?
 
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If you know what the stain is and what the material is - sure.
 
What I actually mean, is it possible on the basis of theoretical consideration of the formula of any organic substance, to find whether it is soluble in an organic solvent.
 
boblalux said:
What I actually mean, is it possible on the basis of theoretical consideration of the formula of any organic substance, to find whether it is soluble in an organic solvent.

Yes. Since like dissolves like. Any LC handbook will have a list of solvents with a polarity index. If you know what the stain is (polar vs. non-polar), then you can find a solvent with a suitable polarity from the list of solvents.
 

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