Probability of an event occurring at least once over n trials

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helpmeplzzz
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There is a 1 in 4 chance that on any given sexual encounter, Joe will contract an STD. If Joe has sex 4 times, what are the chances of him having an STD?
 
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So how would you do it for the probability of Joe contracting an STD twice out of those 4 occasions?

I think you would have to do a combination for this?
 
As this is misplaced homework-type question, I am locking it. This thread was also posted in the Precalc section under Homework & Coursework.