- #1
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I guess proteases have a very broad spectrum of substrates while glycosidases are very specific? Is that correct?
Proteases and Glycosidases: Specificity and Substrate Diversity?
- Thread starter Monique
- Start date
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SUMMARY
Proteases exhibit a broad spectrum of substrate activity, while glycosidases demonstrate high specificity, particularly in the degradation of sugars. Lysosomal storage diseases are primarily linked to deficiencies in glycosidase enzymes rather than proteases, as glycosidases typically operate with a one enzyme to one substrate model. In contrast, proteases can compensate for deficiencies due to their broader substrate range, allowing other proteases to digest accumulating substrates effectively.
PREREQUISITES- Understanding of enzyme specificity and substrate interactions
- Knowledge of lysosomal storage diseases and their biochemical implications
- Familiarity with protease and glycosidase functions
- Basic biochemistry concepts related to protein and sugar metabolism
- Research the mechanisms of glycosidase enzymes in lysosomal storage diseases
- Explore protease specificity and its implications in biochemical pathways
- Study the role of glycosidases in carbohydrate metabolism
- Investigate therapeutic approaches for lysosomal storage diseases
Biochemists, molecular biologists, medical researchers, and healthcare professionals interested in enzyme functions and their roles in metabolic disorders.
- #2
rockind78
- 78
- 0
Well according to my sources, a glycosidase is active in the degredation of sugars, while proteases break down proteins.
http://cancerweb.ncl.ac.uk/cgi-bin/omd?query=glycosidase
http://cancerweb.ncl.ac.uk/cgi-bin/omd?query=protease
http://cancerweb.ncl.ac.uk/cgi-bin/omd?query=glycosidase
http://cancerweb.ncl.ac.uk/cgi-bin/omd?query=protease
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- #3
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You are right, but what I was getting at is that lysosomal storage disease are mainly caused by deficiencies in glycosidase enzymes and not proteases. I thought that the reason for that would be that glycosidases work 1 enzyme 1 substrate, while proteases are more generally active. If you are deficient in a proteases, other proteases would still be able to digest the accumulating substrate. I guess?
- #4
rockind78
- 78
- 0
Sorry,
I totally misread your question there.
I am not familiar with the lysosomal storage disease or glycosidases so much either, but I do know that proteases contain the potential to be quite specific based on the amino acid side chains that are contained within the peptide. Don't know if that helps at all, but hopefully it does.
I totally misread your question there.
I am not familiar with the lysosomal storage disease or glycosidases so much either, but I do know that proteases contain the potential to be quite specific based on the amino acid side chains that are contained within the peptide. Don't know if that helps at all, but hopefully it does.
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